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Azithromycin

ANTIBIOTICS & ANTIINFECTIVES

MACROLIDES - [ ANTIBIOTICS & ANTIINFECTIVES ]

Azithromycin is a macrolide antibiotic. It is less active than erythromycin against gram positive bacteria but more active against H.influenzae. It has substantial ctivity against M. catarrhalis, Chlamydia spp., L. pneumophila, B. burgdorferi, Mycoplasma pneumoniae, and H. pylori and has increased activity against M. avium-intracellulare. (1)

Acute bacterial sinusitis in adults Community-acquired pneumonia in adults and children 6 months and older Uncomplicated genital chlamydial infections and trachoma. (2,3)

Hypersensitivity reactions Cholestatic jaundice/hepatic dysfunction (2)

Allergic and skin reactions Hepatotoxicity Clostridium difficile-associated diarrhea Exacerbation of myasthenia gravis QT Prolongation Gastrointestinal Disturbances like diarrhea, nausea, abdominal pain and vomiting. (2)

Warfarin: Potentiation of the effects of warfarin (2)

Safety is not established in < 6months of age (2)

500 mg is given on the first day, and then 250 mg per day is given for days 2 through 5. A single 2-g dose of extended-release microspheres is an alternative regimen for treatment of community-acquired pneumonia or acute exacerbations of chronic bronchitis (1)

1. Macdougall C, Chambers HF. Protein synthesis inhibitors and miscellaneous antibacterial agents. In: Brunton L, Chabner B, Knollmann B eds. Goodman & Gilman’s The Pharmacological basis of Therapeutics. 12th ed. USA: McGraw Hill; 2011: 1521-1547. 2. Zmax [Internet]. [cited 2013 Aug 24]. Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/050797s017lbl.pdf 3. National Formulary of India. 4 th ed. Government of India, Ministry of Health and Family Welfare. India: Indian Pharmacopoeia Commission; 2011.