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Amantadine

ANTIBIOTICS & ANTIINFECTIVES

ANTIVIRALS - [ ANTIBIOTICS & ANTIINFECTIVES ]

Amantadine is a tricyclic amine which inhibits the replication of the influenza A virus. It inhibits the viral uncoating and also late assembly of the viral assembly (1)

Influenza A Prophylaxis Influenza A Treatment (2)

hypersensitivity to amantadine hydrochloride (2)

nausea, dizziness and insomnia depression, anxiety and irritability, hallucinations, confusion, anorexia, dry mouth, constipation, ataxia, livedo reticularis, peripheral edema, orthostatic hypotension, headache, somnolence, nervousness, dream abnormality, agitation, dry nose, diarrhea and fatigue Death due to acute anticholinergic activity. Suicide attempts Seizures congestive heart failure Neuroleptic malignant syndrome Increased association with melanoma (2)

Anti-cholinergic drugs: Potentiation of their effects Thioridazine: Worsening of tremors Quinine and quinidine: reduced renal clearance of amantadine Live attenuated influenza vaccine: Amantadine should not be administered within 2 weeks before or 48 hours after vaccine (2)

Excreted in human milk, hence use is not recommended in nursing mothers Safety is not established <1years of age Elderly have decreased renal function which might result in increased incidence of toxicity in these patients. (2)

Dosage for Prophylaxis and Treatment of Uncomplicated Influenza A Virus Illness Adult: 200 mg once a day 1-9 years: 4.4 to 8.8 mg/kg/day not exceeding 150 mg/day 9-12 years: 100 mg twice a day (2)

1. Acosta EP, Flexner C. Antiviral agents (nonretroviral). In: Brunton L, Chabner B, Knollmann B eds. Goodman & Gilman’s The Pharmacological basis of Therapeutics. 12th ed. USA: McGraw Hill; 2011:1593-1622. 2. Symmetrel [cited 2013 Aug 25]. Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/016023s041,018101s016lbl.pdf