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Alpha Interferons

ANTIBIOTICS & ANTIINFECTIVES

ANTIVIRALS - [ ANTIBIOTICS & ANTIINFECTIVES ]

Interferons are cytokines which have antiviral, immunomodulatory, and antiproliferative activities. Interferons stimulate the cytotoxic activity of lymphocytes, natural killer cells, and macrophages; and upregulate class I major histocompatibility (MHC) antigens and other surface markers. (1)

Hairy cell leukemia. Chronic hepatitis C Philadelphia chromosome positive CML (2)

Hypersensitivity to alpha interferon or its components Autoimmune hepatitis Hepatic decompensation (2)

Depressive iilness and suicidal behavior, including suicidal ideation, suicide attempt, and suicides Flu like symptoms Nausea, vomiting, diarrhea, abdominal pain, flatulence Injection site reaction, alopecia, rash, pruritis Aggrevates hypothyroidism and hyperthyroidism Pancreatitis (2)

Theophylline: Decreased clearance of theophylline Zidovudine: Myelosuppresion (2)

Potential for serious adverse reactions from the drug in nursing infants can occur Safety is not established in <18 years of age. (2)

Hairy cell leukaemia induction: 3 million IU daily for 16 to 24 weeks. Maintenance 3 million IU three times a week. Treatment for 6 months approx. Kaposi’s Sarcoma: 36 million IU for 10 to 12 weeks, maintenance 36 million IU three times a week. (3)

1. Acosta EP, Flexner C. Antiviral agents (nonretroviral). In: Brunton L, Chabner B, Knollmann B eds. Goodman & Gilman’s The Pharmacological basis of Therapeutics. 12th ed. USA: McGraw Hill; 2011:1593-1622. 2. ROFERON-A [cited 2013 Aug 25]. Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2006/103145s5060LBL.pdf 3. National Formulary of India. 4 th ed. Government of India, Ministry of Health and Family Welfare. India: Indian Pharmacopoeia Commission; 2011.