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Abacavir is a nucleoside reverse transcriptase inhibitor which is a purine gaunosine analogue. It is the sole approved guanosine analogue used for the treatment of HIV. It is primarily active against HIV-1. (1)

Abacavir is used in combination with other antiretroviral agents,for the treatment of HIV-1. (2)

Hypersensitivity to abacavir or any other component of the formulation Moderate to severe hepatic impairment. (2)

Hypersensitivity reaction Lactic acidosis Hepatomegaly Immune reconstitution syndrome Myocardial infarction Fat redistribution Sleep disorders, dreams, headache, nausea, fatigue, diarrhea, rashes, abdominal pain, depressive disorder, dizziness, bronchitis, vomiting (2)

Ethanol: Ethanol decreases excretion of of abacavir thereby increasing its concentration Methadone: An increased dose of methadone might be necessary in some patients on methadone maintenance therapy (2)

Lactating mothers should be instructed not to breastfeed if receiving Abacavir. Dose selection for elderly should be cautious, since there is a greater frequency of hepatic, renal, or cardiac dysfunction, concurrent disease or other drug therapy. (2)

Adult: 300 mg twice daily or 600 mg once daily Child: 3 months to 12 years: 8 mg/kg body weight every 12 h (max. 600 mg daily). (3)

1. Flexner C. Antiretroviral agents and treatment of HIV infection. In: Brunton L, Chabner B, Knollmann B eds. Goodman & Gilman’s The Pharmacological basis of Therapeutics. 12th ed. USA: McGraw Hill; 2011:1623-1664. 2. Ziagen [cited 2013 Aug 29]. Available from:,020978s029lbl.pdf 3. National Formulary of India. 4 th ed. Government of India, Ministry of Health and Family Welfare. India: Indian Pharmacopoeia Commission; 2011.