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Artemether is a semisynthetic derivative of Artemisinin. It is used in the treatment of malaria alongwith combination of lumefantrine. (1)

Treatment of acute, uncomplicated malaria infections due to Plasmodium falciparum in patients of 5 kg bodyweight alongwith lumefantrine. (2)

Hypersensitivity to artemether or other exipients of the formulation. Strong inducers of CYP3A4 result in decreased concentration of artemether and loss of the anitmalarial activity. (2)

Hypersensitivity Headache, dizziness, anorexia, asthenia, pyrexia, chills, fatigue Arthralgia, myalgia Nausea, vomiting, abdominal pain, diarrhea Sleep disorders, insomnia Palpitation, hepatomegaly, splenomegaly, anaemia Cough, pruritis, rash, vertigo (2)

Rifampicin: Rifampicin is a CYP3A4 inducer which might decrease the concentration of artemether. Ketoconazole, protease inhibitors: These drugs inhibit CYP3A4 and increase artemether drug levels. Hormonal contraceptives: Reduced effectiveness of hormonal contraceptives (2)

Artemether is eliminated in milk and caution must be exercised while administering the drug to pregnant women. Safety and efficacy is not established in <5kg weight children Dose selection for an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. (2)

Oral Adult-160 mg in two divided doses on first day followed by 80 mg once a day for next four days. Intramuscular injection Adult- 80 mg twice a day for 3 days. Child-1.6 mg/kg body weight twice a day followed by 1.6 mg/kg body weight once a day for 4 days, alternatively 1.6 mg/kg body weight twice a day for 3 days

1. Vinetz JM, Clain J, Bounkeua V, Eastman RT, Fidock D. Chemotherapy of malaria. In: Brunton L, Chabner B, Knollmann B eds. Goodman & Gilman’s The Pharmacological basis of Therapeutics. 12th ed. China: McGraw Hill; 2011. p1383- 1418. 2. Coartem. [cited 2013 Sept 3]. Available from: 3. National Formulary of India. 4 th ed. Government of India, Ministry of Health and Family Welfare. India: Indian Pharmacopoeia Commission; 2011.