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Apraclonidine is a drug used in the treatment of glaucoma. It is a selective α2 adrenergic agonist and is lipophilic, which aids its easy corneal penetration. It decreases both the aqueous humor production and increases its outflow thereby decreasing the intraocular pressure.(1)

Control or prevent postsurgical elevations in intraocular pressure that occur in patients after argon laser trabeculplasty, argon laser iridotomy or Nd:YAG posterior capsulotomy (2)

Hypersensitivity to the drug or any constituents of the formulation or clonidine. Patients receiving monoamine oxidase inhibitor therapy. (2)

Ocular: Conjunctival blanching, upper lid elevation, mydriasis, burning, discomfort, foreign body sensation, dryness, itching, hypotony, blurred or dimmed vision, allergic response, conjunctival microhemorrhage. Gastrointestinal: Abdominal pain, diarrhea, stomach discomfort, emesis Cardiovascular: Bradycardia, vasovagal attack, palpitations, orthostatic episode. Central Nervous System: Insomnia, dream disturbances, irritability, decreased libido (2)

Safety and efficacy is not established in pediatric patients. (2)

One drop of Apraclonidine Ophthalmic Solution should be instilled in the scheduled operative eye one hour before initiating anterior segment laser surgery and a second drop should be instilled to the same eye immediately upon completion of the laser surgical procedure. (2)

1. GG reference 2. Iopidine [cited 2013 sept 23]. Available from:,019lbl.pdf