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Acyclovir 0.3%



Activity against HSV types I and II and varicella-zoster virus is due to intracellular conversion of aciclovir to the monophosphate by viral thymidine kinase with subsequent conversion to the diphosphate and active triphosphate by cellular enzymes. This active form inhibits viral DNA synthesis and replication by interfering with viral DNA polymerase enzyme and being incorporated into viral DNA.(1,2,3)

Herpes simplex keratitis (1,2,3)

Hypersensitivity Glaucoma (1,2,3)

Eye application may produce stinging, superficial punctate keratopathy, blepharitis or conjunctivitis. (1,2,3)

Minimal with topical use When absorb systemically probenecid decreases urinary excretion and increases half-life. Risk of renal impairment increased by other nephrotoxic drugs. (1,2,3)

Adult- Herpes simplex keratitis: apply 3% w/w ointment 5 times daily for 3 days. (1,2,3)

1. Katzung BG, Masters SB, Trevor AJ, editors. Basic & Clinical Pharmacology. 12th ed. New York: McGraw Hill; 2012 2. Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s The Pharmacological Basis of Therapeutics. 12th ed. China: McGraw Hill; 2011 3. National Formulary of India. 4 th ed. Government of India, Ministry of Health and Family Welfare. India: Indian Pharmacopoeia Commission; 2011.