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Atropine

EYE

MYDRIATICS & CYCLOPLEGICS - [ EYE ]

Atropine is an anticholinergic drug. It blocks the cholinergic stimulation to the accommodative muscle of the ciliary body and the sphincter muscle of the iris in the eye. This helps in papillary dilation and cyclopegia i.e. inhibition of accommodation. (1)

Mydriasis and/or cycloplegia. For cycloplegic refraction, for papillary dilation desired in inflammatory conditions of the iris and uveal tract. (2)

Hypersensitivity to the drug or any constituents of the formulation Primary glaucoma. Narrow anterior chamber angle (2)

Follicular conjunctivitis, vascular congestion, edema, exudate, and an eczematoid dermatitis. Hypotension with progressive respiratory depression, coma and death (2)

Safety and efficacy is not established in pediatric patients. (2)

Adult Cycloplegic refraction: 1 drop (1%) twice daily for 1 to 2 days before procedure or a single application of 1 drop (1%), 1 h before procedure. Iritis and uveitis: 1 drop (0.5 to 1%) up to 4 times daily. Child Cycloplegic refraction 3 months to 1 year: 0.1%; 1 to 5 years: 0.1 to 0.5% Over 5 years: 0.5 to 1.0%. 1 drop twice daily for 1 to 3 days before procedure with a further dose given 1 h before procedure. (3)

1. Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s The Pharmacological Basis of Therapeutics. 12th ed. China: McGraw Hill; 2011. 2. Travantan Z [cited 2013 sept 23]. Available from: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=5549684b-1724-45ca-b67b-590c62b7c149#nlm34068-7 3. National Formulary of India. 4 th ed. Government of India, Ministry of Health and Family Welfare. India: Indian Pharmacopoeia Commission; 2011.