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Amoxapine

CENTRAL NERVOUS SYSTEM

ANTIDEPRESSANTS - [ CENTRAL NERVOUS SYSTEM ]

Amoxapine is an antidepressant of the dibenzoxazepine class, chemically distinct from the dibenzazepines, dibenzocycloheptenes, and dibenzoxepines.Amoxapine is sometimes associated with a parkinsonian syndrome due to its D 2-blocking action.(1,2)

Amoxapine is indicated for the relief of symptoms of depression in patients with neurotic or reactive depressive disorders as well as endogenous and psychotic depressions. It is indicated for depression accompanied by anxiety or agitation.(2)

Prior hypersensitivity to dibenzoxazepine compounds. It should not be given concomitantly with monoamine oxidase inhibitors.(2)

Anxiety, insomnia, restlessness, nervousness, palpitations, tremors, confusion, excitement, nightmares, ataxia. Drowsiness, dry mouth, constipation and blurred vision. Patients with major depressive disorder (mdd), both adult and pediatric, may experience worsening of their depression and/or the emergence of suicidal ideation and behavior. Neuroleptic malignant syndrome (NMS). Tardive dyskinesia.(2)

It should not be given concomitantly with monoamine oxidase inhibitors.(2)

Amoxapine, like many other systemic drugs, is excreted in human milk. Because effects of the drug on infants are unknown, caution should be exercised when amoxapine is administered to nursing women. Safety and effectiveness in the pediatric population have not been established.(2)

Usual starting dosage is 50 mg two or three times daily. Depending upon tolerance, dosage may be increased to 100 mg two or three times daily by the end of the first week. For maintenance therapy at dosages of 300 mg or less, a single dose at bedtime is recommended.(2)

1. O’Donnel JM, Shelton RC. Drug Therapy of Depression and Anxiety Disorders. In: Brunton L, Chabner B, Knollmann B eds. Goodman & Gilman’s The Pharmacological basis of Therapeutics. 12th ed. China: McGraw Hill; 2011. P. 397-415. 2. AMOXAPINE [Internet]. [cited 2013 Sept 15]. Available from: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=a16297df-3158-48db-85e5-5cd506885556