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Adapalene binds to specific retinoic acid nuclear receptors which normalises the differentiation of follicular epithelial cells resulting in decreased microcomedone formation. (1,2,3)

Topical/Cutaneous; Acne (1,2)

Hypersensitivity (1,2)

Mild skin irritation, scaling, erythema, cutaneous dryness, sensations of stinging and burning, pruritus. (1,2)

Increased irritation may occur with medicated or abrasive soaps, products with a pronounced drying effect and those containing alcohol or astringents (1,2)

Avoided in patients with sunburn, eczema. Avoid excessive exposure to sunlight or UV irradiation. Keep away from the eyes, lips, nostrils and mucous membranes. Do not apply to cuts, abrasions, scaly or flaky skin, or patches of sunburned skin. Use with caution with preparations containing sulfur, resorcinol, or salicylic acid. (1,2)

Topical/Cutaneous Acne Adult: As 0.1% solution/cream/gel: Apply thinly onto affected areas once daily at night after cleansing. (1,2)

1. Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s The Pharmacological Basis of Therapeutics. 12th ed. China: McGraw Hill; 2011. 2. Adapalene. cited on 11th October 2013) available online from website