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Acamprosate

CENTRAL NERVOUS SYSTEM

POISONING & DRUG DEPENDANCE - [ METABOLISM ]

Acamprosate is an analogue of GABA. It decreases drinking frequency and reduces relapse drinking in abstinent alcoholics and appears to have efficacy similar to that of naltrexone. {1}

Maintenance of abstinence from alcohol in patients with alcohol dependence who are abstinent at treatment initiation. {2}

Previous hypersensitivity to acamprosate or any of its components Severe renal Impairment {2}

Asthenia Pain Anorexia Diarrhea Flatulence Nausea Anxiety Depression Dizziness Dry mouth Insomnia Paresthesia Pruritus Sweating {2}

Renal Impairment: Dose reduction required for moderate renal impairment; contraindicated in severe renal impairment {2}

666 mg (two 333 mg tablets) taken three times daily {2}

1. Schuckit M. Ethanol and Methanol. In: Brunton L, Chabner B, Knollmann B eds. Goodman & Gilman’s The Pharmacological basis of Therapeutics. 12th ed. USA: McGraw Hill; 2011: 629- 48 2. Campral [Internet] [cited 2013 Oct 20]. Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021431s015lbl.pdf