Search Result for Drug name

Anastrozole

NEO PLASTIC DISORDERS

ANTIESTROGENS & ANTIANDROGENS - [ NEO PLASTIC DISORDERS ]

Anastrozole prevents conversion of androstenedione to estrone and testosterone to oestradiol by inhibiting aromatase, thus leading to significantly reduced serum oestradiol concentrations. (1,2,3)

Advanced or locally advanced breast cancer, Adjuvant treatment in early breast cancer (1,2,3)

Pregnancy. Hypersensitivity, premenopausal women (1,2,3)

Hot flushes, vaginal dryness, vaginal bleeding, hair thinning, anorexia, nausea, vomiting, diarrhoea, headache, arthralgia, bone fractures, rash, oedema, myalgia, fever, weight gain, leucopenia, flu-like syndrome, asthenia, dizziness, drowsiness, abnormal liver enzyme values, thrombophloebitis, anaphylaxis. (1,2,3)

Efficacy decreased by oestrogens. Plasma concentrations decreased by tamoxifen.

Cautious administration should be advised in hypertension, renal & liver function impairment patients Cautious administration should be advised in elderly, (2,3)

Adult: In postmenopausal women: 1 mg daily. Adjuvant treatment may be continued for up to 5 yr (2,3)

1. Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s The Pharmacological Basis of Therapeutics. 12th ed. China: McGraw Hill; 2011 2. Katzung BG, Masters SB, Trevor AJ, editors. Basic & Clinical Pharmacology. 12th ed. New York: McGraw Hill; 2011 3. Anastrazole. (cited on 11th october 2013) available online from website http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/020541s027lbl.pdf