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Aspirin

CENTRAL NERVOUS SYSTEM

ANALGESICS - [ CENTRAL NERVOUS SYSTEM ]

Aspirin is indicated for headache, transient musculo-skeletal pain, dysmenorrhoea and pyrexia. In inflammatory conditions, most physicians prefer anti-inflammatory treatment with another NSAID which may be better tolerated and more convenient for the patient.(1)

Rheumatoid arthritis, Juvenile rheumatoid arthritis. Spondyloarthropathies. Osteoarthritis.(2)

Known hypersensitivity to aspirin or other NSAID.(2)

Gastritis, dyspepsia, peptic ulcers. Hypothermia, fever, thirst. Hypotension, tachycardia. Confusion, disorientation, coma. Dehydration, hypokalemia, metabolic acidosis. Coagulopathy, DIC, thrombocytopenis. Hypo or hyperglycemia. severe allergic reactions like asthma or facial swelling.(2,3)

Aggravates hyponatremic and hypotensive effects of ACE inhibitors. Increases levels of acetazolamide and thus its toxicity. If used with anticoagulents, increases risk of bleeding. Hypotensive effect of beta blockers and diuretics is diminished.(2)

Avoid use in patients of renal failure and hepatic failure. Should be taken by pregnant female if clearly needed. Should be avoided seven days prior to labor and delivery. Should be avoided by nursing mothers.(2)

For RA and osteoarthritis: 3g/day in divided doses. For Juvenile RA: 90-130mg/kg/day in divided doses. For spondyloarthropathies: 4g/day in divided doses.(2)

1. Grosser T, Smyth E, FitzGerald GA. Anti-inflammatory, Antipyretic, and Analgesic Agents; Pharmacotherapy of Gout. In: Brunton L, Chabner B, Knollmann B eds. Goodman & Gilman’s The Pharmacological basis of Therapeutics. 12th ed. China: McGraw Hill; 2011. P. 960-1004. 2. ASPIRIN [Internet]. [cited 2013 Sept 15]. Available from: http://labeling.bayercare.com/omr/online/aspirin-regimen-bayer-regular-strength-325-mg.pdf 3. National Formulary of India. 4 th ed. Government of India, Ministry of Health and Family Welfare. India: Indian Pharmacopoeia Commission; 2011